Heatmaps depicting changes in translation upon imatinib and rapamycin treatment for genes either significantly translationally activated (A,C) or repressed (B,D) by v-Abl.

<p>Normalized average change (median = 0, SD = 1) was used to display changes in translation upon treatment with imatinib versus rapamycin as indicated (A,B) or changes in translation versus changes in mRNA abundance upon treatment with imatinib (C,D). Heatmaps are ordered by increasing change in translation upon rapamycin treatment (A,B) or by increasing change in mRNA abundance upon imatinib treatment (C,D). In cases where multiple oligos represent a gene, the oligo with the biggest change in translation upon imatinib treatment was used. Genes that were regulated translationally by imatinib but not rapamycin (A,B) or regulated translationally but not at the level of mRNA abundance by imatinib treatment (C,D) are highlighted in yellow (10% FDR cutoff, SAM). (SD, standard deviation).