Re-expression of 14-3-3σ in MDA-MB-231 cells inhibits bone metastasis in vivo.
- Julia Inglés-Esteve (163946)
- Mònica Morales (163951)
- Alba Dalmases (163953)
- Ricard Garcia-Carbonell (163957)
- Alba Jené-Sanz (163962)
- Núria López-Bigas (5649316)
- Mar Iglesias (161944)
- Cristina Ruiz-Herguido (163964)
- Ana Rovira (163968)
- Federico Rojo (163971)
- Joan Albanell (163974)
- Roger R. Gomis (163978)
- Anna Bigas (163983)
- Lluís Espinosa (163986)
Publication date
May 2012
DOIAbstract
<p>(A) Representative bioluminescence images of mice injected with 0.5×10<sup>6</sup> control or 14-3-3σ-overexpressing MDA-MB-231 cells 4 weeks after intracardiac injection. (B) Scattered plot of the dorsal photon flux (normalized to Day 0) at different times after injection. Each symbol represents one animal (C–D) H&E staining and IHC for 14-3-3σ (C) and IHC for ki-67 (D) of a representative bone-metastasis from a mouse injected with control (MT) or 14-3-3σ-expressing cells. (E–F) Quantification of cells expressing the proliferation marker ki-67 (E) and number of mitotic figures in the H&E staining (F) determined by counting 10 different high power fields per tumor (3 tumors counted for each group).</p
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