Increased cathepsin B mRNA after HIV infection.

<p>MDM from 8 different donors were inoculated with HIV-1_ADA or with serum-free media (uninfected controls) for 12 days and cell pellets collected at 3, 7, and 12 days post-infection. Changes in mRNA levels are shown as <i>Fold change</i> = 2 ^ΔΔCt = 2 ^{(Δ Ct control – Δ Ct experimental)} for cathepsin B (white), cystatin B (grey), and cystatin C (black). The mRNA levels of cystatins B and C remained similar after HIV infection. A significant increase in mRNA expression was found for cathepsin B in HIV infected MDM at 12 days compared to 3 (*p = 0.038, B) and 7 dpi (*p = 0.028).