Transcriptome classification of THP-1 cells to W-Beijing strains as well as the lab strain H37Rv.

<p>(<b>A</b>) Sample classification of THP-1 transcriptome responses to <i>Mtb</i> W-Beijing and H37Rv strains.W-Beijing strains from the same node (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0038367#pone-0038367-g001" target="_blank">Figure 1</a>) were highlighted by the same color. For example, two CHN50 strains (CHN50.1 and CHN50.2) from node Bmyc26 were colored in black. (<b>B</b>) Component plane presentation integrated self-organizing map (CPP-SOM) of host transcriptomic responses to 11 different W-Beijing family strains as well as duplicated H37Rv (columns) at 3 time points (rows). Each presentation illustrates a sample- and time-specific transcriptome map, in which all the up-regulated (represented by neurons in red), down-regulated (represented by neurons in blue) and moderately regulated (represented by neurons in yellow and green) genes were well delineated. Linking these presentations allows visual-easy comparisons of transcriptome changes across time points and strains.