DNA damage induced apoptosis is regulated by CLPTM1L.

<p>A) Annexin V binding by flow cytometry of A549 cells with CLPTM1L knockdown after 48 hours treatment with cisplatin. B) Relative caspase 3/7 activity in H838 cells with CLPTM1L knockdown after 48 hours treatment with cisplatin. Error bars represent one standard deviation from the mean. **- p<0.01 * - p<0.02 by two-tailed Student’s T-Test. C) Micrographs of A549 cells with CLPTM1L knockdown after 24 hours treatment with 50<b> </b>µM cisplatin showing increased genotoxic cell death upon loss of CLPTM1L.