Relative density of nsSNVs (<i>rdnsv</i>) in different gene sets as estimated with different SNV datasets.

<p>Nervous system genes (NSG, light grey) show a smaller <i>rdnsv</i> than immune system genes (ISG, medium grey) or randomly sampled genes (RSG, dark grey) in a European diploid genome sequence (A, C) and a pooled set of 200 European exome sequences (B, D). The greater <i>rdnsv</i> in the pooled 200 exomes than the individual genome indicates an enrichment of nsSNVs among rare SNVs.