Insertion of fibril-forming motifs from other amyloidogenic proteins into the disabled Tau protein can retrieve its ability to form fibrils−TEM measurements.

<p>Negative-stain transmission electron micrographs of the following mutants: insertion of SNQNNF (A), NNQQNY (B), QQQQQQ (C), GVATVA (D), GGVVIA (E), IFQINS (F), NHVTLS (G), and SQAIIH (H) into Tau_244–372/ΔPHF6/ΔPHF6* at the location of PHF6 after incubation for 24 h. All the scale bars were 200 nm.