Cytokine concentrations in supernatants from T lymphocytes cocultured with DCs(pg/mL).

<p>The data was expressed as mean±SEM, IL-2, IFN-γ, IL-4, and IL-10 concentration in the supernatants from T lymphocytes in 4 self-limited HCV infections and 5 chronic HCV subjects, cocultured with DCs loaded with single epitope peptide or multiple epitope peptide mixtures. Triplicate wells of every peptide in the same experiment were used. The single peptides include 4 previously reported epitope peptides (E2 (723–731), NS3 (1073–1081), NS3 (1585–1593), and NS5b (2594–2602)), 7 predicted peptides and HLA-A2 restricted CTL HBV envelope epitope peptide (WLSLLVPFV) as an unrelated-peptide control. The epitope peptide mixture (mix1∼mix14) contains 2 to 6 single epitopes in each mixture. <b>A</b>. IL-2 concentration. <b>B</b>. IFN-γ concentration. <b>C</b>. IL-4 concentration. <b>D</b>. IL-10 concentration. *P<0.05, **P<0.01.