<div><p>Hepatic gluconeogenesis is required for maintaining blood glucose homeostasis; yet, in diabetes mellitus, this process is unrestrained and is a major contributor to fasting hyperglycemia. To date, the impacts of chromatin modifying enzymes and chromatin landscape on gluconeogenesis are poorly understood. Through catalyzing the removal of methyl groups from specific lysine residues in the histone tail, histone demethylases modulate chromatin structure and, hence, gene expression. Here we perform an RNA interference screen against the known histone demethylases and identify a histone H3 lysine 36 (H3K36) demethylase, Jhdm1a, as a key negative regulator of gluconeogenic gene expression. In vivo, silencing of Jhdm1a promotes liver gluco...
AbstractChromatin remodelling events, especially histone modifications are proposed to form the main...
AbstractEpigenetic mechanisms such as DNA methylation, histone modification and microRNA changes hav...
International audienceAberrant histone methylation profile is reported to correlate with the developm...
Hepatic gluconeogenesis is required for maintaining blood glucose homeostasis; yet, in diabetes mell...
Hepatic gluconeogenesis is required for maintaining blood glucose homeostasis; yet, in diabetes mell...
Hepatic gluconeogenesis is required for maintaining blood glucose homeostasis; yet, in diabetes mell...
Aberrant gluconeogenic gene expression is associated with diabetes, glycogen storage disease, and li...
Aberrant gluconeogenic gene expression is associated with diabetes, glycogen storage disease, and li...
Aims: Insufficient insulin release by β-cells is the primary etiology in type 2 diabetes and coinci...
Accelerated rates of vascular complications are associated with diabetes mellitus. Environmental fac...
Globally, obesity and diabetes (particularly type 2 diabetes) represents a major challenge to world ...
International audienceCirculating pancreatic glucagon is increased during fasting and maintains gluc...
Organismal physiology is built upon the foundation of molecular processes. A central axis to maintai...
Histone methylation plays important roles in the regulation of chromatin dynamics and transcription....
International audienceIn order to identify epigenetic mechanisms through which hyperglycemia can aff...
AbstractChromatin remodelling events, especially histone modifications are proposed to form the main...
AbstractEpigenetic mechanisms such as DNA methylation, histone modification and microRNA changes hav...
International audienceAberrant histone methylation profile is reported to correlate with the developm...
Hepatic gluconeogenesis is required for maintaining blood glucose homeostasis; yet, in diabetes mell...
Hepatic gluconeogenesis is required for maintaining blood glucose homeostasis; yet, in diabetes mell...
Hepatic gluconeogenesis is required for maintaining blood glucose homeostasis; yet, in diabetes mell...
Aberrant gluconeogenic gene expression is associated with diabetes, glycogen storage disease, and li...
Aberrant gluconeogenic gene expression is associated with diabetes, glycogen storage disease, and li...
Aims: Insufficient insulin release by β-cells is the primary etiology in type 2 diabetes and coinci...
Accelerated rates of vascular complications are associated with diabetes mellitus. Environmental fac...
Globally, obesity and diabetes (particularly type 2 diabetes) represents a major challenge to world ...
International audienceCirculating pancreatic glucagon is increased during fasting and maintains gluc...
Organismal physiology is built upon the foundation of molecular processes. A central axis to maintai...
Histone methylation plays important roles in the regulation of chromatin dynamics and transcription....
International audienceIn order to identify epigenetic mechanisms through which hyperglycemia can aff...
AbstractChromatin remodelling events, especially histone modifications are proposed to form the main...
AbstractEpigenetic mechanisms such as DNA methylation, histone modification and microRNA changes hav...
International audienceAberrant histone methylation profile is reported to correlate with the developm...