Functional characterisation of <i>EF-G2mt</i> equivalent SNPs in the yeast <i>MEF2</i> gene.

<p>(A) Growth of wild-type, <i>mef2</i> deletion strain and <i>mef2</i> mutants in yeast medium containing either glucose as the carbon source or the non-fermentable carbon source glycerol. Cells from exponentially growing cultures were serially diluted and 5 µl of each dilution spotted onto each plate. Growth was assessed after 72 hours incubation at 30°C. (B) Percentage cell viability of yeast <i>mef2</i> mutants in 110 µM atorvastatin relative to viability of the wild-type strain following exposure to atorvastatin for 5 days. Data represent mean ± SEM (n = 3). A one-way ANOVA followed by a Dunnett's multiple comparison test was used to compare the mean percentage viability of the <i>mef2</i> variants to that of the wild-type. ***<i>P</i><0.001.