Ruthenium-Catalyzed Highly Regioselective Cyclization of Ketoximes with Alkynes by C–H Bond Activation: A Practical Route to Synthesize Substituted Isoquinolines

Aromatic and heteroaromatic ketoximes underwent cyclization with alkynes in the presence of a catalytic amount of [{RuCl₂(<i>p</i>-cymene)}₂] and NaOAc to give isoquinoline derivatives in good to excellent yields in a highly regioselective manner