Correlation of the relative compression rate with gene co-expression, functional similarity, cellular localization, and phylogenetic profile similarity for 12 Yeast networks.

<p>For all interacting pairs of proteins for which we have information about both, we compute the proportion – or assortativity ratio – of interacting proteins that are significantly co-expressed, share a cellular function, are found in at least one common cellular compartment, and have similar phylogenetic profiles. We normalize these ratios by subtracting the average proportion found for equivalent randomized networks similarly to the relative compression rate (see Methods for details). (<b>A</b>) Relative compression rate versus relative proportion of interacting proteins that are co-expressed. The Kendall correlation () is the highest of all four studied correlations. (<b>B</b>) Relative compression rate versus relative proportion of interacting proteins that share at least one functional role. (<b>C</b>) Relative compression rate versus relative proportion of interacting proteins that share at least one cellular localization. (<b>D</b>) Relative compression rate versus relative proportion of interacting proteins that have similar phylogenetic profiles. The low Kendall correlation () and poor -value () indicates a poor correspondence between relative compression rate and shared evolution.