An overview of the metabolic imbalances in SLE.

<p>The most significant metabolic alterations in SLE have been organized into different biochemical pathways, including glycolysis (A), Krebs cycle (B), fatty acid oxidation (C), amino acid pools (D), lipid biosynthesis (E), essential FA (F), eicosanoid biosynthesis (G) and methyl group interchange pathways (H) leading to glutathione generation (I). Metabolites that were elevated in SLE are in red font, while reduced metabolites are in green font. Mitochondrial events are blue-boxed, while events that take place in the endoplasmic reticulum are yellow-boxed. Salient metabolic consequences that can potentially contribute to the manifestations of SLE are highlighted in pink.