Ursolic acid reduces diet-induced obesity and glucose intolerance.

<p>Mice were provided ad libitum access to high fat diet (HFD) lacking or containing 0.14% ursolic acid (UA) for 6 weeks. Data are means ± SEM. *P<0.05 by t-test. (A) Total body weight was measured at the indicated times. n≥12 mice per diet. (B) Weights of bilateral epididymal and retroperitoneal fat pads. n = 10 mice per diet. (C) Fasting blood glucose levels. Mice were fasted for 16 h prior to tail vein glucose measurements. n≥12 mice per diet. (D) Glucose tolerance tests. Following a 16 h fast, 1 g/kg glucose was administered by i.p. injection at time = 0 min. Blood glucose was then measured via the tail vein at the indicated times. n = 10 mice per diet. Left, blood glucose values. Right, areas under the curves.