Results of simulation studies.

<p>(A) Simulation on the effect of replicate sample size and interaction strength. The black and red dashed lines indicate the base line (AUC = 0.5) and a high prediction performance (AUC = 0.8), respectively. The performance of <i>PAN</i>, as measured by AUC, increases along with the number of replicates and interaction strength. (B) Simulation on the effect of prior incorporation. The prediction accuracy (AUC = 0.65) of the global model is marked by the black dashed line. The performance is improved gradually by bringing in more prior information about functional interactions, but reduced by adding more noise in the prior.