<p>(A) Schematic representation of the NSE-globin-parkin transgene construct. The expression of wild type parkin is under the control of NSE promoter. (B) Transcriptional expression of transgene in different regions of parkin transgenic mouse brain. The pair of primers P1 and P2 could identify mRNA expression (∼400 bp). Samples were from the cortex, hippocampus, striatum, substantia nigra, cerebellum and remaining of the brains from transgenic and wild type mice. (C) Transcriptional expression of parkin detected by real-time PCR in the cortex, hippocampus, striatum, substantia nigra, cerebellum and remaining parts of the brain, parkin-specific primers (parkin forward and parkin reverse) were used. (D) Expression of Parkin protein in the cor...
<p>(<b>A</b>) Schematic representation of the transgene construct. The cDNA for mouse PAR1 was inser...
<p>(A) Schematic depicts the generation of PITX3-IRES2-tTA/tetO-GCaMP3 (PITX3/GC) double-transgenic ...
<p>(<b>A-B</b>) The transgenic construct (as evidenced by the GFP tag) was shown to be present in so...
<div><p>Mutations in the <em>parkin</em> gene are currently thought to be the most common cause of r...
Mutations in the parkin gene are currently thought to be the most common cause of recessive familial...
Parkin gene is associated with the development of autosomal recessive juvenile parkinsonism (Kitada ...
Mutations in a protein designated Parkin were shown to be involved in the pathogenesis of autosomal ...
Transgenic mice were used as an assay system for the isolation and characterization of the promoter ...
<p>Samples were collected at 1 day or 3 days from the striatum (A, B) and the substantia nigra (C, D...
Mutations in PARK2 (parkin) can result in Parkinson's disease (PD). Parkin shares a bidirectional pr...
<p>Western blot showing α-synuclein protein in the striatum of young (A) and old (C) mice after sali...
<p>(A) Schematic representation of transgene construction. (B) Southern blot analysis performed on 1...
<p>A: Schematic of the construct used for the generation of transgenic mice expressing PA-GFP::NLS u...
As mammalian genome projects move towards completion, the attention of molecular neuroscientists is ...
<p>(A) Schematic of the Thy1.2 expression construct used to generate ubiquilin-1 transgenic mice. Hu...
<p>(<b>A</b>) Schematic representation of the transgene construct. The cDNA for mouse PAR1 was inser...
<p>(A) Schematic depicts the generation of PITX3-IRES2-tTA/tetO-GCaMP3 (PITX3/GC) double-transgenic ...
<p>(<b>A-B</b>) The transgenic construct (as evidenced by the GFP tag) was shown to be present in so...
<div><p>Mutations in the <em>parkin</em> gene are currently thought to be the most common cause of r...
Mutations in the parkin gene are currently thought to be the most common cause of recessive familial...
Parkin gene is associated with the development of autosomal recessive juvenile parkinsonism (Kitada ...
Mutations in a protein designated Parkin were shown to be involved in the pathogenesis of autosomal ...
Transgenic mice were used as an assay system for the isolation and characterization of the promoter ...
<p>Samples were collected at 1 day or 3 days from the striatum (A, B) and the substantia nigra (C, D...
Mutations in PARK2 (parkin) can result in Parkinson's disease (PD). Parkin shares a bidirectional pr...
<p>Western blot showing α-synuclein protein in the striatum of young (A) and old (C) mice after sali...
<p>(A) Schematic representation of transgene construction. (B) Southern blot analysis performed on 1...
<p>A: Schematic of the construct used for the generation of transgenic mice expressing PA-GFP::NLS u...
As mammalian genome projects move towards completion, the attention of molecular neuroscientists is ...
<p>(A) Schematic of the Thy1.2 expression construct used to generate ubiquilin-1 transgenic mice. Hu...
<p>(<b>A</b>) Schematic representation of the transgene construct. The cDNA for mouse PAR1 was inser...
<p>(A) Schematic depicts the generation of PITX3-IRES2-tTA/tetO-GCaMP3 (PITX3/GC) double-transgenic ...
<p>(<b>A-B</b>) The transgenic construct (as evidenced by the GFP tag) was shown to be present in so...