Correlates of protection six weeks after infection.

<p>A, the pulmonary responses obtained using ICS and flow cytometry six weeks after infection shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0039909#pone-0039909-g003" target="_blank">figure 3</a> after stimulation with ESAT-6 (A) or the H4-vaccine antigens Ag85B- and TB10.4 (B) were correlated to the corresponding mean log₁₀ CFU value shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0039909#pone-0039909-g004" target="_blank">figure 4</a>. Points represent mean percentage and SEM (vertical) of CD4 T cells producing IFNγ/TNFα (A) or IFNγ/TNFα/IL-2 (B) in response to stimulation with indicated antigens from 3 pools of two lungs plotted on the y-axis and mean and SEM (horizontal) log₁₀ CFU values of mice lungs (N = 29 for non-vaccinated controls and n = 9−10 for the vaccination groups) on the x-axis. Each point represents one group in the order BCG/H4-IC31, BCG, H4-IC31, and non vaccinated from left. *, p<0.05, **, p<0.01, using Pearson’s product-moment correlation coefficient (r) and correlation test.