Immunodominance of predicted Gag- and Nef-specific CD4+ T cell responses.

<p>(A) Overall immunogenic analysis illustrating the individual peptides that generated a CD4+ T cell response. The vertical axis represents the total number of individuals that recognised each peptide, while the horizontal axis illustrates the individual peptide numbers within each HIV region. (B) Distribution of the number of recognised peptides per individual. (C) Percentage of peptides from different HIV proteins that induced a CD4+ T cell response. (D) Fraction of tested peptides from different HIV protein regions that generated CD4+ T cell responses per individual. The statistical analysis was performed with a one-way ANOVA and a non-parametric Kruskal Wallis test with Dunn’s multiple comparison test to compare all of the pairs of columns; *<i>P</i><0.05, **<i>P</i><0.01 and ***<i>P</i><0.001. The data are derived from 38 independent experiments (mean and SEM).