Bone cell activities in the femora of PYY^−/− mice.

<p>In the distal femoral metaphysis, lack of PYY signaling results in greater bone formation rate (A,C) due to greater mineral apposition rate (MAR) with no change in mineralizing surface (C,I) in both genders. Endocortical MAR at the mid femur was also greater in PYY^−/− compared to wild-type. Parameters of cancellous bone resorption as indicated by osteoclast surface and number (B,D) are similar between PYY^−/− and wild-type controls. Representative images of endocortical MAR are shown in E. Scale bar represents 10 µm. Mean ± SEM of 5–18 mice per group are shown. *p<0.05, **p<0.005, ***p<0.001 versus wild-type (WT).