Alignment of amino acid sequences of the isoforms 1, 2, 3, 4, and 5 of GSK3β gene of porcine.

<p>GSK3β is spliced to five different kinds of mRNAs: GSK3β1, GSK3β2, GSK3β3, GSK3β4 and GSK3β5, which encode five proteins with 420, 433, 399, 387 and 400 amino acids, respectively. GSK3β2 have a 13 amino acid insert in the kinase domain. GSK3β3 and GSK3β4 contain the identical serine/threonine kinase domain but vary in their N-terminus. GSK3β5 lacks a 20 amino acid (203–222) in the kinase domain inculding three important phosphorylation site Lys 205, Tyr 216, Tyr 220.