Relationships between sex phenotype and haplotype on chr-3 and -4.

<p>(A) In Family A, all individuals homozygous for the C allele at Marker ID29464 chr-4∶61,176,889 bp were male and 84% of individuals heterozygous at this marker were female. (B) In Family B, loci on chr-3 and -4 appear to interact to influence sex (marker ID32525 chr-4∶61,422,807bp; marker ID29552 chr-3∶20,676,406bp). Individuals homozygous for grandsire-derived alleles at the chr-4 locus developed as males independent of their chr-3 genotype and animals homozygous for granddam-derived alleles were all or nearly all female without regard to their chr-3 genotype. On the other hand, individuals that were homozygous for the grandsire-derived alleles at the chr-3 locus were male independent of their genotype at the chr-4 locus.