Modification of the angular vestibulo-ocular and maculo-ocular reflexes in adult centrifuged <i>C57Bl/6J</i> mice.

<p>A, Averaged oculomotor fields in non-centrifuged (<i>control</i>) and centrifuged (<i>Adult-HG)</i> mice across tested frequencies. Line and surface of the ellipses present the mean and standard deviation of the population, respectively. The slopes of the ellipses are the mean slope of the individuals’ ellipses. Oculomotor fields were not altered in <i>adult-HG</i> compared to <i>control</i>. B, Bode plots of horizontal VOR in dark gain and phase during horizontal sinusoidal rotations. There was no consistent effect of centrifugation on the responses to sinusoidal rotations. C–D, Raw traces showing steady state response of the same adult-HG mouse followed at time +1 month (C) and +6 months (D) after centrifugation. Note the absence of nystagmus on the horizontal traces and the strong reduction in the amplitude of the vertical movements at 1 month. E, horizontal bias (E) for non-centrifuged (<i>control</i>) and centrifuged (<i>Adult-HG)</i> mice in all tested conditions. Horizontal biases (E) were significantly affected in 50°/s CCW condition. Right panel presents individual (small symbols) and mean of the populations (large symbols). Solid lines indicate the evolution of individuals’ bias at +1 and +6 months after centrifugation (black: improved responses; dotted: no or little improvement in the responses). F, vertical gain (F) for non-centrifuged (<i>controls</i>) and centrifuged (<i>Adult-HG)</i> mice in all tested conditions. Tp, Table position; EVp, Eye Vertical position; EHp, Eye Horizontal position. Black or purple asterisks indicate <i>p</i><0.05 between <i>control</i> and <i>Adult-HG+1 or Adult-HG+6,</i> respectively.