Measurement of CD39 ADPase activity on microparticles from healthy controls compared with IPAH patients.

<p>Representative thin layer chromatography (A) shows increased dephosphorylation of 14C-labeled ADP to AMP and adenosine (ADO) in samples incubated with microparticles isolated from a patient with IPAH compared to a healthy control. Quantification of radiolabeled ADP, AMP and ADO in TLC samples from Controls (B) and IPAH patients (C) revealed a significant increase in the percentage of ADP dephosphorylated to AMP and adensoine, as shown in (D).