Response of OR orthologs to 42 chemically diverse odors.

<p>(A) Tuning curves of human, chimp and macaque OR2W1 orthologs tested against 42 odors using a cAMP-mediated luciferase assay <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1002821#pgen.1002821-Zhuang3" target="_blank">[26]</a>. Odorants are ordered along the x-axis according to the response elicited from the human OR2W1, with the best ligands closer to the center. Y-axis represents the luciferase response to an odor at 100 µM (n = 3, ± S.E.). Negative values on the y-axis indicate the odor elicited an inhibitory response on OR signaling. See <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1002821#pgen.1002821.s006" target="_blank">Figure S6</a> for additional tuning curves. (B) Response of chimp and macaque OR2W1 orthologs (variant responses) plotted against the human OR2W1 response using the data from (A). X-axis and y-axis are response in luciferase assay at 100 µM (n = 3, ± S.E.). The black line represents the unit-slope line. Odor abbreviations in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1002821#pgen.1002821.s016" target="_blank">Table S3</a>.