Free energy landscape.

<p>2D-free energy profiles as a function of (A) and , (B) and , (C) and , (D) and . measures the global degree of binding process. , and measure the degree of binding of N-helix, C-helix, Chz motif in Chz.core to the histones. There are two distinct binding pathways and intermediate states in (A), (D), only one pathway formed one intermediate state in (B) and only one pathway without intermediate state in (C). Free energy is in the unit of .