Measures of subnetwork organization.

<p>(A, B) Clustering (<i>C</i>) and (C, D) modularity (<i>M</i>) coefficients for the subnetworks generated by the VRGs, contextualized in the TRN and PPIN. <i>Rand</i> indicates the average value for random subnetworks (100 replicates). NS denotes non-significant value following a one-tailed <i>z</i>-test. Horizontal dashed lines represent the cutoff value for statistical significance.