Global gene expression changes.

<p>Panel A shows a heat map of the 25% (7685 probes) most variable genes in the dataset for all samples. Each sample day represents three individual animals, except the control group (CTRL, n = 6). HD and LD indicate high dose and low dose, respectively. D1 through D7 designates the day of euthanasia. Panel B illustrates gene expression profiles of 1997 significantly changed probes with a fold change larger than +/−2 in at least one group when compared to the control group. The average fold change from the three animals within each group is shown. Red designate up-regulated genes, blue down regulated genes, where a more intense color illustrates a more pronounced fold change. The Venn diagram in panel C shows the number of probes up or down regulated after infection by any of the three strains (177 genes), by two of the three strains (228, 131 and 29 genes) and the number of probes aberrantly expressed in a strain specific pattern.