The performance of the test set of GPCRs and kinases using different methods by 10 simulation times test of 10-fold cross validation.

<p>All performances were evaluated based on top 5 predicted lists. NBI, network-based inference; NWNBI, node weighted network-based inference; EWNBI, edge weighted network-based inference; DBSI-T, drug-based similarity inference with Tanimoto similarity score; DBSI-C, DBSI with Cosine similarity score; DBSI-F, DBSI with Forbes similarity score; DBSI-R, DBSI with Russell-rao similarity score; TBSI, target-based similarity inference; R, recall; ER, recall enhancement; AUC, the area under the receiver operating characteristic curve; C_i (P_a, P_b, …, P_m) represents the prioritization of new targets for a given chemical; P_j (C_a, C_b, …, C_n) represents the prioritization of new chemicals for a given protein. *The standard deviation of the performance measured by 10 independent simulation times test of 10-fold cross validation.