Protective effects of flavonoids in DSS-induced colitis in mice.

<p>Histopathological examination of the colon of mice exposed to DSS and/or flavones (Baicalein, Baicalin) is illustrated. The histology (inset shows higher magnification views) represents the prototypical injury to the colon induced by DSS. <i>Pxr^+/+</i>: wild-type mice; <i>Pxr^−/−</i>: <i>Pxr</i>-null mice; <i>hPXR</i>: humanized PXR mice. –DSS: DSS untreated mice; +DSS: DSS treated mice; single black arrow: vehicle exposed mucosa; double black arrow: flavonoids exposed mucosa. Scale bar, 50 µM.