D4 receptor activation increases gamma oscillation power.

<p>LFP recordings of kainate-induced gamma oscillation and dopamine D4R agonist (PD168077, 100 nM) without and with prior application of D4R antagonist (L745,870, 500 nM or Clozapine (2 µM). <b>A.</b> Example traces of LFP recordings, showing an increase with D4R activation <b>B.</b> Power spectra of traces shown in A (kainate recording in black, subsequent recording with PD168077 in grey). <b>C.</b> Example traces of LFP recordings, showing the D4 effect is blocked with application of clozapine. <b>D.</b> Power spectra of traces shown in C. (kainate recording in black, clozapine as dotted line, and PD168077 in grey). <b>E.</b> Summary bar diagram of power (in % relative to initial kainate power, mean ± SEM). D4R activation significantly increases LFP gamma power, which is prevented by prior application of D4R antagonist or Clozapine. * P<0.05, ** P<0.01, *** P<0.001 (in unpaired t-tests).