Global analysis of gene expression changes in the lungs of influenza infected C57BL/6J mice.

<p>(A) Weight loss of PR8M-infected C57BL/6J mice over two months after infection showing mean values +/− SEM. (B) A Principle Component Analysis (PCA) of all samples taken over the investigated time interval on the basis of the expression of all genes was conducted and single replicates were plotted with reference to the first two principal components (PC1, PC2) covering 57.3% of the variance. Symbols and colors indicate biological replicate samples prepared at the same day p.i. from different individuals. (C) A total of 3,595 differentially expressed (DE) genes were identified over the course of two months after infection. Bars indicate the number of DE genes on each day p.i. Colors indicate the number of DE genes that were newly detected at any given day, <i>e.g.</i> dark red: DE genes newly identified on day 1 p.i. compared to controls; dark green: DE genes that appeared at day 8 p.i. and were not differentially expressed at any time before. y-axis: total number of DE genes, x-axis: day after infection.