SHIP-1 interacts with XIAP in the course of NOD2 signaling.

<p>THP1 cells were treated with MDP (100 µg/mL) for indicated periods and proteins were extracted. Samples were immunoprecipitated with an anti-XIAP antibody or with an IgG control (Ig). Coimmunoprecipitated SHIP-1 was revealed by immunoblotting with an anti-SHIP-1 antibody. Expression of different proteins in the whole cell lysate (INPUT) was verified by immunoblotting with anti-XIAP, anti-SHIP-1 and anti-p-IκBα antibodies, respectively.