Carbohydrate metabolism.

<p>(A) Heatmap depicting the log basis 2 fold changes in metabolite (rows) concentration determined in liver tissues between matched pairs (columns) of homozygous (G/G, <i>Bcs1l</i>^G/G) and littermate control (A/A, <i>Bcs1l</i>^A/A) mice. Columns (i.e. matched pairs) are reordered by hierarchical clustering (HCA, Ward aggregation method) using the age group (14, 24 and more than 30 days, >30) to label the tree leaves. Metabolites are grouped according to chemical classification. (B) Explicit fold changes with their corresponding 95% confidence intervals for all the carbohydrate intermediates measured in the three age groups. Significance levels: +, q<0.2; **, q<0.01 and ***, q<0.001. DHAP+3-PGA: mixture of dihydroxyacetonephosphate and 3-phosphoglyceraldehyde. (C) Periodic acid-Schiff staining of liver sections showing progressive glycogen depletion from 24 to 34 days old homozygotes.