<p>(A) Log<sub>2</sub> fold changes of the acylcarnitines found significant at a false discovery rate <0.1 in the three age groups (14, 24 and >30 days) between matched pairs of homozygous (G/G, <i>Bcs1l</i><sup>G/G</sup>) and control (A/A, <i>Bcs1l</i><sup>A/A</sup>) mice. Metabolites are presented in the increasing order of their molecular weight. Significance levels are defined as: +, q<0.2; *, q<0.05; **, q<0.01 and ***, q<0.001. (B) Oil-Red-O staining showing microvesicular lipid accumulation in hepatocytes of sick animal (34d), only.</p
Background Non-alcoholic steatohepatitis (NASH) is a common disease and feeding mice a methionine-ch...
BACKGROUND: The 4-thia fatty acid tetradecylthiopropionic acid (TTP) is known to inhibit mitochondri...
Acylcarnitines are fatty acid metabolism intermediates that emerge from the cellular energy metaboli...
<p>For each time point data from three different mice have been used (n = 3) and are presented as me...
The New Zealand obese (NZO) mouse is a polygenic model for obesity and diabetes with obese females a...
<div><p>(A) Serum acylcarnitine analysis of MCAD<sup>+/+</sup> (<i>n</i> = 4) and MCAD<sup>−/−</sup>...
Metabolic myopathies due to disorders of lipid metabolism are a heterogeneous group of diseases. New...
The purpose of this study was to test whether heterozygotes of juvenile visceral steatosis mice, a m...
We recently reported that feeding mice in their early life a diet containing a lipid structure more ...
<p>In liver extracts, fatty acids were measured using gas-liquid chromotography, enzyme activities w...
Background Emerging data support a role for lipids in non-alcoholic steatohepatitis (NASH) and hepat...
<p>a. Hepatic acyl carnitine profile in 18 h fasted and 5 h re-fed mice. Data are mean ± SEM, n = 4 ...
<p>(A) Heatmap depicting the log basis 2 fold changes in metabolite (rows) concentration determined ...
<p><b>(A)</b> Volcano plot (fold-change vs significance) of the comparison between metabolites of th...
<p>Liver tissue slides were stained with oil red O and photographed under a microscope. Compared wit...
Background Non-alcoholic steatohepatitis (NASH) is a common disease and feeding mice a methionine-ch...
BACKGROUND: The 4-thia fatty acid tetradecylthiopropionic acid (TTP) is known to inhibit mitochondri...
Acylcarnitines are fatty acid metabolism intermediates that emerge from the cellular energy metaboli...
<p>For each time point data from three different mice have been used (n = 3) and are presented as me...
The New Zealand obese (NZO) mouse is a polygenic model for obesity and diabetes with obese females a...
<div><p>(A) Serum acylcarnitine analysis of MCAD<sup>+/+</sup> (<i>n</i> = 4) and MCAD<sup>−/−</sup>...
Metabolic myopathies due to disorders of lipid metabolism are a heterogeneous group of diseases. New...
The purpose of this study was to test whether heterozygotes of juvenile visceral steatosis mice, a m...
We recently reported that feeding mice in their early life a diet containing a lipid structure more ...
<p>In liver extracts, fatty acids were measured using gas-liquid chromotography, enzyme activities w...
Background Emerging data support a role for lipids in non-alcoholic steatohepatitis (NASH) and hepat...
<p>a. Hepatic acyl carnitine profile in 18 h fasted and 5 h re-fed mice. Data are mean ± SEM, n = 4 ...
<p>(A) Heatmap depicting the log basis 2 fold changes in metabolite (rows) concentration determined ...
<p><b>(A)</b> Volcano plot (fold-change vs significance) of the comparison between metabolites of th...
<p>Liver tissue slides were stained with oil red O and photographed under a microscope. Compared wit...
Background Non-alcoholic steatohepatitis (NASH) is a common disease and feeding mice a methionine-ch...
BACKGROUND: The 4-thia fatty acid tetradecylthiopropionic acid (TTP) is known to inhibit mitochondri...
Acylcarnitines are fatty acid metabolism intermediates that emerge from the cellular energy metaboli...