Mitochondrial morphological parameters: differential effects of HIV-1 infection and ART on lymphocytes and monocytes.

<p>(<b>A, E</b>) Discriminant analysis using three mitochondrial morphological parameters. The five cohort populations are delineated by their 95% confidence circles around the means. The two perpendicular axes describe the combined variance of the parameters analysed (lymphocytes: 90.66%, monocytes: 98.73%). The contributions of each parameter to the variances on the X and Y axes are shown in the insets. Inset: The 3 mitochondrial parameters used were: Vv%: Volume density (lymphocytes: see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0041129#pone-0041129-g005" target="_blank">Figure 5B</a>; monocytes: see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0041129#pone-0041129-g005" target="_blank">Figure 5F</a>). Frag: Fragmentation (lymphocytes: see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0041129#pone-0041129-g005" target="_blank">Figure 5C</a>; monocytes: see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0041129#pone-0041129-g005" target="_blank">Figure 5G</a>). Bran: Branching (lymphocytes: see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0041129#pone-0041129-g005" target="_blank">Figure 5D</a>; monocytes: see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0041129#pone-0041129-g005" target="_blank">Figure 5H</a>). (<b>A</b>) Lymphocytes ART naive patients and control subjects are statistically different. Mitochondrial changes induced by HIV infection are partially reduced by ART. (<b>E</b>) Monocytes ART naive patients exhibit no variations compared to control subjects, while significant differences are observed for the three ART groups. (<b>B to D; F to H</b>) Box plots: *p<0,05, **p<0,01.