The point-mutations of ISKNV-vSOCS altered its inhibitory activity in the ISRE-promoter luciferase reporter genes.

<p>Cells were transfected with ISKNV-vSOCSmyc or its mutants, and then treated with IFN-α (5000 U) for 8 h. The activity of the ISRE-promoter luciferase reporter genes was detected. Relative luciferase activity in the cells transfected with empty plasmid after IFN treatment was arbitrarily set as 100. Error bars represent the mean ± S.D. (n = 3). **P<0.01.