<p>(A) Sequence alignment of mouse miR-34a, miR-34b and miR-34c. Differing nucleotides are colored in blue. The seed sequences are in bold. (B–D) MiR-34a and miR-34c expression as detected by qPCR (B,C) and by Northern blotting (D) in tissues of wild-type and p53<sup>−/−</sup> mice.</p
<p><b>(A)</b> qRT-PCR analysis of mRNA levels of p53 transcriptional targets, normalized to <i>GAPDH...
<p>(A) Real-time PCR for miR-34c. (B) Localization of miR-34c in mouse testis at different developme...
<p>Schematic representation of the conservation of a novel microRNA, miR-3615376 among different spe...
<p>qPCR of miR-34a, miR-b and miR-34c in hearts of control, TAC moderate and TAC severe mice. N = 3–...
<p>(A) Targeting and screening strategy for the generation of constitutive and conditional miR-34a K...
<div><p>MicroRNAs belonging to the miR-34 family have been proposed as critical modulators of the p5...
<p><b>(A)</b> Sequence of the miR-34a region in chromosome 1 in miR-34a-KO HCT116 cells compared to ...
<p><b>(A)</b> Sequence of the miR-34a region in chromosome 1 in miR-34a-KO MCF7 cells compared to WT...
<p>(A) MiR-34a and miR-34c expression in serially-passaged wild-type MEFs, as measured by qPCR. Erro...
<p>(<b>A</b>) Conserved seed matches on DGKζ mRNA are designated with the gray box. (<b>B</b> and <b...
MiR-34a, a direct target of p53, has shown to exert potent anti-proliferative effects. It has also b...
miR-34, a tumor suppressor miRNA family transcriptionally activated by p53, is considered a critical...
<div><p>miR-34, a tumor suppressor miRNA family transcriptionally activated by p53, is considered a ...
<p><b>(A)</b><i>TP53</i> mRNA is enriched in Bi-miR-34a PDs in HCT116 cells. mRNA levels were determ...
<p>(<b>A</b>) Expression scatterplot showing relative average expression of affymetrix probes betwee...
<p><b>(A)</b> qRT-PCR analysis of mRNA levels of p53 transcriptional targets, normalized to <i>GAPDH...
<p>(A) Real-time PCR for miR-34c. (B) Localization of miR-34c in mouse testis at different developme...
<p>Schematic representation of the conservation of a novel microRNA, miR-3615376 among different spe...
<p>qPCR of miR-34a, miR-b and miR-34c in hearts of control, TAC moderate and TAC severe mice. N = 3–...
<p>(A) Targeting and screening strategy for the generation of constitutive and conditional miR-34a K...
<div><p>MicroRNAs belonging to the miR-34 family have been proposed as critical modulators of the p5...
<p><b>(A)</b> Sequence of the miR-34a region in chromosome 1 in miR-34a-KO HCT116 cells compared to ...
<p><b>(A)</b> Sequence of the miR-34a region in chromosome 1 in miR-34a-KO MCF7 cells compared to WT...
<p>(A) MiR-34a and miR-34c expression in serially-passaged wild-type MEFs, as measured by qPCR. Erro...
<p>(<b>A</b>) Conserved seed matches on DGKζ mRNA are designated with the gray box. (<b>B</b> and <b...
MiR-34a, a direct target of p53, has shown to exert potent anti-proliferative effects. It has also b...
miR-34, a tumor suppressor miRNA family transcriptionally activated by p53, is considered a critical...
<div><p>miR-34, a tumor suppressor miRNA family transcriptionally activated by p53, is considered a ...
<p><b>(A)</b><i>TP53</i> mRNA is enriched in Bi-miR-34a PDs in HCT116 cells. mRNA levels were determ...
<p>(<b>A</b>) Expression scatterplot showing relative average expression of affymetrix probes betwee...
<p><b>(A)</b> qRT-PCR analysis of mRNA levels of p53 transcriptional targets, normalized to <i>GAPDH...
<p>(A) Real-time PCR for miR-34c. (B) Localization of miR-34c in mouse testis at different developme...
<p>Schematic representation of the conservation of a novel microRNA, miR-3615376 among different spe...