<p>Results are the means ± S.E.M. of 4 to 6 independent experiments.</p>*, **<p>, p<0.05 or p<0.01 respectively, when compared to insulin.</p
There is controversy with respect to molecular characteristics of insulin analogues. We report a ser...
<p>(A) Typical experiments showing real-time effects of IGF1, IGF2, EGF and glargine on PIP<sub>3</s...
AIMS/HYPOTHESIS: There is controversy with respect to molecular characteristics of insulin analogues...
<p>(A) Conversion of glargine into M1 and M2 metabolites. (B) Effects of M1 and M2 on IR/IGF1R hybri...
<p>HEK-293 cells were co-transfected with IRA-Luc/IRA-YFP, IRB-Luc/IRB-YFP, IRA-Luc/IGF1R-YFP or IRB...
<div><h3>Background</h3><p>In diabetic patients, the pharmacokinetics of injected human insulin does...
with regard to their insulin receptor (IR) and IGF-1 receptor (IGF1R) binding and signaling propert...
<p>Results are the means ± S.E.M. of 5 to 6 independent experiments.</p>*, **<p>, p<0.05 or p<0.01 r...
We investigated 1) the ability of purified glargine (GLA), metab-olites 1 (M1) and 2 (M2), IGF-I, an...
<p>IC50 values were determined in scintillation proximity assays for displacement of <sup>125</sup>I...
We investigated 1) the ability of purified glargine (GLA), metabolites 1 (M1) and 2 (M2), IGF-I, and...
Glargine became the first long-acting insulin analogue. Glargine was designed to meet basal insulin ...
Objective: To investigate whether human insulin (HI) and insulin analogues differ in their ability t...
<p>Binding of the insulin analogs to the human IR-A (<b>A</b>) or IR-B (<b>B</b>) was analyzed in a ...
<p>Data are means ± SEM. All analogs were tested at least three times on different days. Activity wa...
There is controversy with respect to molecular characteristics of insulin analogues. We report a ser...
<p>(A) Typical experiments showing real-time effects of IGF1, IGF2, EGF and glargine on PIP<sub>3</s...
AIMS/HYPOTHESIS: There is controversy with respect to molecular characteristics of insulin analogues...
<p>(A) Conversion of glargine into M1 and M2 metabolites. (B) Effects of M1 and M2 on IR/IGF1R hybri...
<p>HEK-293 cells were co-transfected with IRA-Luc/IRA-YFP, IRB-Luc/IRB-YFP, IRA-Luc/IGF1R-YFP or IRB...
<div><h3>Background</h3><p>In diabetic patients, the pharmacokinetics of injected human insulin does...
with regard to their insulin receptor (IR) and IGF-1 receptor (IGF1R) binding and signaling propert...
<p>Results are the means ± S.E.M. of 5 to 6 independent experiments.</p>*, **<p>, p<0.05 or p<0.01 r...
We investigated 1) the ability of purified glargine (GLA), metab-olites 1 (M1) and 2 (M2), IGF-I, an...
<p>IC50 values were determined in scintillation proximity assays for displacement of <sup>125</sup>I...
We investigated 1) the ability of purified glargine (GLA), metabolites 1 (M1) and 2 (M2), IGF-I, and...
Glargine became the first long-acting insulin analogue. Glargine was designed to meet basal insulin ...
Objective: To investigate whether human insulin (HI) and insulin analogues differ in their ability t...
<p>Binding of the insulin analogs to the human IR-A (<b>A</b>) or IR-B (<b>B</b>) was analyzed in a ...
<p>Data are means ± SEM. All analogs were tested at least three times on different days. Activity wa...
There is controversy with respect to molecular characteristics of insulin analogues. We report a ser...
<p>(A) Typical experiments showing real-time effects of IGF1, IGF2, EGF and glargine on PIP<sub>3</s...
AIMS/HYPOTHESIS: There is controversy with respect to molecular characteristics of insulin analogues...
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