Effect of histone lysine mutations on the growth and DNA damage sensitivity of <i>dia2</i>Δ cells.

<p>The <i>dia2</i>Δ mutant, each histone mutant and their corresponding double mutant, containing both the <i>dia2</i>Δ mutation and the indicated histone mutation, were assayed for cell growth and sensitivity towards the DNA damaging agent camptothecin (CPT). A ‘−’ represents no effect on growth or DNA damage sensitivity over the individual single mutants. A ‘+’ represents a synthetic effect in growth on regular media (YPD) or DNA damage sensitivity (growth on medium containing CPT). More+s indicate a more dramatic synthetic effect in comparison with other strains tested. Note that the <i>dia2Δ H4K5,8,12R</i> mutant is synthetic lethal, and therefore, DNA damage sensitivity could not be assessed (n/a).