Isolactarane and Sterpurane Sesquiterpenoids from the Basidiomycete <i>Phlebia uda</i>

Three new sesquiterpenoids, named udasterpurenol A, udalactarane A, and udalactarane B, as well as the known compounds hyphodontal and sterpuric acid have been isolated from the basidiomycete <i>Phlebia uda</i>. These compounds represent the first natural products described from this species. The structures were elucidated by NMR spectroscopy and mass spectrometry. Udalactaranes A and B were isolated as mixtures with their respective epimeric acetals. These mixtures inhibited the spore germination of the plant pathogenic fungus <i>Fusarium graminearum</i> at 10 and 5 μg/mL, respectively, and were active against Jurkat cells with IC₅₀ values of 101 and 42 μM, respectively