Predicted inhibitory activity (pKi) of the selected eight compounds against 47 proteases.

<p>Red, pink, brown, orange circles stand for the first-generation inhibitors, i.e. Saquinavir, Ritonavir, Indinavir, Nelfinavir respectively; Darkgreen, cadetblue, cyan, blue triangles stand for the second-generation ones, i.e. Darunavir, Tipranavir, TMC-126, XV638 respectively. The lines indicate the average values for each of them.