Systemic Cytokine Responses to Bacterial Challenge.

*<p>indicates p<0.05, compared with wild type (ANOVA with Dunnett’s post-test).</p>a<p>Serum was obtained from unmanipulated mice of the indicated genotypes at 11–12 wks of age. At this time point, all of the T/I and T-het/I mice studied had at least mild colitis, whereas WT, <i>Il10</i>^−/−, and <i>Tnf</i>^−/− mice had no evidence of colon inflammation. Data shown is the mean ± SEM of 5 mice tested per group.</p>b<p>Serum was obtained 90 min after i.p. injection of 100 µg LPS. Data shown is the mean ± SEM of 5 mice tested per group.</p>c<p>Serum was obtained 42 hrs after initiating a diet containing 200 ppm of the NSAID piroxicam. Data shown is the mean ± SEM of 4 mice tested per group.