Phenylbutyrate treatment increases global histone H3 acetylation in R6/2 liver and cerebellum.

<p>(A) Western blot demonstrating AcH3 levels in histone extracts from WT and TG R6/2 livers (top), Coomassie blue gel staining demonstrates equal loading (bottom). (B) Integrated densitometry values (IDV) for AcH3 levels in A. (C) Western blot demonstrating AcH3 levels in histone extracts from WT and TG R6/2 cerebellum (top). Coomassie blue gel staining demonstrates equal loading (bottom). (D) Integrated densitometry values (IDV) for AcH3 levels in C. White bars, WT, vehicle (veh) treated (n = 9); Light grey bars, WT, phenylbutyrate (PB) treated (n = 8); Black bars, Tg, vehicle (veh) treated (n = 7); Dark grey bars, Tg, phenylbutyrate (PB) treated (n = 11). *, p-value<0.05. Error bars are standard deviation.