<p>A–B) The kinase library was screened at 10 µM in a single concentration format against enzymatic reactions of A) TBK1 and B) IKKε. The distribution of activity is shown as a frequency histogram based on the number of compounds active at each level (% Inhibition). The data follow a normal distribution.</p
<p><b>A</b>. Graph of ΔTm values of ScreenWell Kinase Inhibitor library hits determined at compound ...
<p>(A) Inhibitory activity of compounds <b>9–27</b> against EGFR and HER2 protein kinases were repre...
<p>Compounds were screened in one of two kinase panels at a concentration of 10 µM. The degree of in...
<p>Number of active compounds (N) detected in each screen for total number detected (unfiltered), nu...
Publicly available kinase inhibitors have been analyzed in detail. Nearly 19000 inhibitors have been...
More than 141 000 inhibitors of human kinases and their activity data were assembled to perform an i...
The discovery of selective inhibitors of biological target proteins is the primary goal of many drug...
<p>A targeted library of 235 compounds was screened for PKD1 activity at 1 µM using an <i>in vitro</...
<p>Listed in this table are all the protein kinases that bound compound <b>122</b> at over 50% at 10...
<p><sup>a</sup>Data were presented as the mean ± standard deviation (S. D.)</p><p>Kinase profiles of...
Drug discovery programs frequently target members of the human kinome and try to identify small mole...
#<p>IC<sub>50</sub> or K<sub>i</sub> of selected kinases inhibited >50% at 0.5 µM from larger kinase...
<p>The score for each phosphosite was predicted by NetworKIN, both for regulated and non-regulated p...
<p>Scatter plot comparison of our IC<sub>50</sub> and T<sub>m</sub> shift data divided into proteins...
<p>(<b>a</b>) Heatmap depicting the activity of the 367 member GSK PKIS against 224 protein kinases,...
<p><b>A</b>. Graph of ΔTm values of ScreenWell Kinase Inhibitor library hits determined at compound ...
<p>(A) Inhibitory activity of compounds <b>9–27</b> against EGFR and HER2 protein kinases were repre...
<p>Compounds were screened in one of two kinase panels at a concentration of 10 µM. The degree of in...
<p>Number of active compounds (N) detected in each screen for total number detected (unfiltered), nu...
Publicly available kinase inhibitors have been analyzed in detail. Nearly 19000 inhibitors have been...
More than 141 000 inhibitors of human kinases and their activity data were assembled to perform an i...
The discovery of selective inhibitors of biological target proteins is the primary goal of many drug...
<p>A targeted library of 235 compounds was screened for PKD1 activity at 1 µM using an <i>in vitro</...
<p>Listed in this table are all the protein kinases that bound compound <b>122</b> at over 50% at 10...
<p><sup>a</sup>Data were presented as the mean ± standard deviation (S. D.)</p><p>Kinase profiles of...
Drug discovery programs frequently target members of the human kinome and try to identify small mole...
#<p>IC<sub>50</sub> or K<sub>i</sub> of selected kinases inhibited >50% at 0.5 µM from larger kinase...
<p>The score for each phosphosite was predicted by NetworKIN, both for regulated and non-regulated p...
<p>Scatter plot comparison of our IC<sub>50</sub> and T<sub>m</sub> shift data divided into proteins...
<p>(<b>a</b>) Heatmap depicting the activity of the 367 member GSK PKIS against 224 protein kinases,...
<p><b>A</b>. Graph of ΔTm values of ScreenWell Kinase Inhibitor library hits determined at compound ...
<p>(A) Inhibitory activity of compounds <b>9–27</b> against EGFR and HER2 protein kinases were repre...
<p>Compounds were screened in one of two kinase panels at a concentration of 10 µM. The degree of in...