Activation of human CD8⁺ T cells in the presence of TWS119 favors a young/memory phenotype.

<p>CD127 and CD133 expression in CD8⁺ T cell sub-populations defined by expression of CD45RA and CD62L (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0041074#pone-0041074-g001" target="_blank">Figure 1A</a>) following treatment with TWS119. (<b>A</b>) Representative histograms of total CD8⁺ T cells expressing CD127 or CD133 after a 5-day anti-CD3/IL-2 activation with or without TWS119. (<b>B–C</b>) Percentage of CD8⁺ T cells expressing, respectively, CD127 (<b>B</b>) and CD133 (<b>C</b>) in total CD8⁺ T cell population (Total), and in each CD45RA/CD62L-defined population from <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0041074#pone-0041074-g001" target="_blank">Figure 1A</a>, for 9 healthy donors in B and 5 in C. (<b>D</b>) Percentage of CD8⁺ T cells expressing both CD127 and CD133 markers in total CD8⁺ T cell population (total) and in each CD45RA/CD62L-defined population from <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0041074#pone-0041074-g001" target="_blank">Figure 1A</a> for 5 healthy donors. * <i>P</i><0.004.