<p>Number of active compounds (N) detected in each screen for total number detected (unfiltered), number after drug like filtering (filtered.drug-like), hits from the LOPAC and Kinase libraries, and the number of chemical clusters and singleton hits as described in the text.</p
Abstract Background The current chemical space of known small molecules is estimated to exceed 1060 ...
Protein kinases form a consistent class of promising drug targets, and several efforts have been mad...
Drug discovery programs frequently target members of the human kinome and try to identify small mole...
<p>A–B) The kinase library was screened at 10 µM in a single concentration format against enzymatic ...
We carried out a systematic evaluation of target selectivity profiles across three recent large-scal...
The discovery of selective inhibitors of biological target proteins is the primary goal of many drug...
<p>A: Hierarchical clustering of inhibitory profiles of all kinase drugs in a panel of more than 300...
Kinases regulate cell growth, movement, and death. Deregulated kinase activity is a frequent cause o...
Kinase is one of the most productive classes of established targets, but the majority of approved dr...
We carried out a systematic evaluation of target selectivity profiles across three recent large-scal...
<p>Scores of pharmacologically linked kinase proteins and analysis compared to other datasets.</p
ABSTRACT: Large corpora of kinase small molecule inhibitor data are accessible to public sector rese...
<p>All hit compounds identified were chemical clustered using pubchem finger prints. (A) The major c...
Rapid quantitative methods for characterizing small molecules, peptides, proteins, or RNAs in a broa...
<p>Scatter plot comparison of our IC<sub>50</sub> and T<sub>m</sub> shift data divided into proteins...
Abstract Background The current chemical space of known small molecules is estimated to exceed 1060 ...
Protein kinases form a consistent class of promising drug targets, and several efforts have been mad...
Drug discovery programs frequently target members of the human kinome and try to identify small mole...
<p>A–B) The kinase library was screened at 10 µM in a single concentration format against enzymatic ...
We carried out a systematic evaluation of target selectivity profiles across three recent large-scal...
The discovery of selective inhibitors of biological target proteins is the primary goal of many drug...
<p>A: Hierarchical clustering of inhibitory profiles of all kinase drugs in a panel of more than 300...
Kinases regulate cell growth, movement, and death. Deregulated kinase activity is a frequent cause o...
Kinase is one of the most productive classes of established targets, but the majority of approved dr...
We carried out a systematic evaluation of target selectivity profiles across three recent large-scal...
<p>Scores of pharmacologically linked kinase proteins and analysis compared to other datasets.</p
ABSTRACT: Large corpora of kinase small molecule inhibitor data are accessible to public sector rese...
<p>All hit compounds identified were chemical clustered using pubchem finger prints. (A) The major c...
Rapid quantitative methods for characterizing small molecules, peptides, proteins, or RNAs in a broa...
<p>Scatter plot comparison of our IC<sub>50</sub> and T<sub>m</sub> shift data divided into proteins...
Abstract Background The current chemical space of known small molecules is estimated to exceed 1060 ...
Protein kinases form a consistent class of promising drug targets, and several efforts have been mad...
Drug discovery programs frequently target members of the human kinome and try to identify small mole...