Design principles of the foldamer-dendrimer conjugates.

<p>Foldamers based on unnatural β-amino acid building blocks (R: proteinogenic side chains) fold into short helices (<b>A</b>). Foldamers exhibiting weak binding to the target can be identified by using NMR spectroscopic methods (<b>B</b>). Chemoselective ligation of the synthetic recognition segments with flexible linkers yields amplified affinity to the target (<b>C</b>). Blue spheres are schematic representation of the Aβ oligomers.