Gene set enrichment analysis of HCMV-primed NKG2D⁺ CD4⁺ T-cells.

<p>(<b>A</b>) Gene set enrichment analysis was performed as described in <i>Materials and Methods</i>. The indicated score is the –log10(<i>P</i>) of the multiple testing corrected significance. (<b>B</b>) Volcano plots are shown for 5 of the 19 gene sets and pathways which were significantly different when comparing NKG2D⁺ CD4⁺ T-cells with NKG2D^– CD4⁺ T-cells. Volcano plots of significant gene sets were created by plotting the significance of expression change using a paired Student’s <i>t</i>-test and the fold-change as the log of ratio between the average expression values in each group. Black squares indicate genes that have higher expression in the NKG2D⁺ CD4⁺ T-cells, whereas gray squares indicate genes that have higher expression in the NKG2D^– CD4⁺ T-cells.