Biomechanical analysis.

<p><b>A,</b> Load-displacement curve from a WT tibia showing yield load, maximum load, fracture load and gradient of the linear elastic phase (stiffness). <b>B,</b> Curves from WT and <i>Sparc</i>. <b>C,</b> Graphs showing mean (solid line), 1.0SD (dotted line) and 2.0SD (grey box) for yield load, maximum load, fracture load and stiffness of WT (n = 77) mice. Values for <i>Sparc</i> in red. <b>D,</b> Energy dissipated prior to maximum load (DE_ML, purple) and elastic stored energy at maximum load (ESE_ML, yellow). <b>E,</b> Graph showing mean ±1.0SD and 2.0SD for the proportion DE_ML/(DE_ML+ESE_ML) prior to maximum load for WT mice. Value for <i>Sparc</i> in red. <b>F,</b> Energy dissipated prior to fracture (DE_F, purple) and elastic stored energy at fracture (ESE_F, yellow). <b>G,</b> Graph showing mean ±1.0SD and 2.0SD for the proportion DE_F/(DE_F+ESE_F) prior to fracture for WT mice. Value for <i>Sparc</i> in red. y-axis scale reflects angular transformation to normalize data distribution.