miR-7 expression is decreased in breast cancer and is associated with tumor metastasis.

<p>(A) The expression level of mature miR-7 in breast cancer (n = 42) or normal breast tissues (n = 27) was determined using quantitative PCR. Both breast cancer and normal breast are fresh tissues. Box-plot lines represent medians and interquartile ranges of the normalized threshold values; whiskers and spots indicate 10–90 percentiles and the remaining data points. (B) The relative expression of mature miR-7 in 19 non-metastatic breast cancer tissue and 23 metastatic breast cancer tissue samples. The expression level of mature miR-7 is normalized to U6 small nuclear RNA.